Evaluation of the in-vivo Antiplasmodial Activities of Ochna membranacea (Oliv) Ochnaceae Leaves and Stembark extracts in mice

Malaria is an infectious disease with high mortality rate in Africa. Development of resistance to antimalarial drugs current clinical use such as chloroquine and Artemisinin; along poor health systems funding shortfalls have elevated the importance continuous search for novel agents. The lead compounds from which artemisinin were derived isolated plants. Therefore, there potential discovery new effective treatment Ochna membranacea (Oliv) Ochnaceae among several plants used traditionally against diseases including malaria no scientific validation. This study investigated antiplasmodial effect crude methanol leaves extract stembark coded OMCLE OMCSE respectively Plasmodium berghei chloroquine-resistant strain. Acute toxicity studies carried out using standard protocol. prophylactic, suppressive curative effects extracts evaluated at doses 500, 1000 1500 mg/kg Ryley Peters’ method. Chloroquine (5 mg/kg) artesunate tests, while 1.2 pyrimethamine was prophylactic test. oral median lethal dose (LD50) estimated be > 5000 mg/kg. All graded gave a statistically significant (P<0.05) effect. Only highest inhibition parasitaemia. In test, all tested both exhibited suppression parasitaemia compared negative control. conclusion, suggests that O. membranaceapossesses activity making it potent candidate newer antimalarials.